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“The Anti-Aging Protein Klotho: A novel therapeutic target for neurodegenerative diseases”
2020 Virtual Symposium / Carmela Abraham of Boston University at Massachusetts General Hospital
August 2020
Relevant papers published by Drs. Carmela Abraham, Cidi Chen, Ella Zeldich and collaborators include:
Aging-suppressor Klotho: Prospects in diagnostics and therapeutics
C R Abraham, Anne Li
C R Abraham, Anne Li
October 17,2022
AAV-mediated expression of secreted and transmembrane š¼Klotho isoforms rescues relevant aging hallmarks in senescent SAMP8 mice
J Roig-Soriano, C GriƱƔn-FerrĆ©, J F Espinosa-Parrilla , C R Abraham, A Bosch, M PallĆ s, Miguel ChillĆ³n
J Roig-Soriano, C GriƱƔn-FerrĆ©, J F Espinosa-Parrilla , C R Abraham, A Bosch, M PallĆ s, Miguel ChillĆ³n
February 20,2022
A Transgenic Model Reveals the Role of Klotho in Pancreatic Cancer Development and Paves the Way for New Klotho-Based Therapy
Tammi Arbel Rubinstein, Inbal Reuveni, Arkadi Hesin, Anat Klein-Goldberg, Hannes Olauson, Tobias E. Larsson, Carmela R. Abraham, Ella Zeldich, AssumpciĆ³ Bosch, Miguel ChillĆ³n, Kenneth Samuel Hollander, Ayelet Shabtay-Orbach, Gilad W. Vainer, Ido Wolf,and Tami Rubi
Tammi Arbel Rubinstein, Inbal Reuveni, Arkadi Hesin, Anat Klein-Goldberg, Hannes Olauson, Tobias E. Larsson, Carmela R. Abraham, Ella Zeldich, AssumpciĆ³ Bosch, Miguel ChillĆ³n, Kenneth Samuel Hollander, Ayelet Shabtay-Orbach, Gilad W. Vainer, Ido Wolf,and Tami Rubi
December 15, 2021
miR-142-3p Regulates Cortical Oligodendrocyte Gene Co-expression Networks Associated with Tauopathy.
Hinman, JD, Ngo, K, Kim, D, Chen, C-D, Abraham, CR, Kawaguchi, R, Coppola, G, Goth, K, Bellusci, S, Hernandez, I, Kosik, KS and Fogel, BL
Hinman, JD, Ngo, K, Kim, D, Chen, C-D, Abraham, CR, Kawaguchi, R, Coppola, G, Goth, K, Bellusci, S, Hernandez, I, Kosik, KS and Fogel, BL
February 9, 2021
Klotho, PTSD, and advanced epigenetic age in cortical tissue.
Wolf, E. J.,Ā Chen, C.D., Zhao, X., Zhou, Z., Morrison, F. G., Daskalakis, N. P., Stone, A., Schichman, S., Garza Grenier, J., Fein-Schaffer, D., Huber, B. R., Traumatic Stress Brain Research Group, Abraham, CR, Miller, M. W. and Logue, M. W.
Wolf, E. J.,Ā Chen, C.D., Zhao, X., Zhou, Z., Morrison, F. G., Daskalakis, N. P., Stone, A., Schichman, S., Garza Grenier, J., Fein-Schaffer, D., Huber, B. R., Traumatic Stress Brain Research Group, Abraham, CR, Miller, M. W. and Logue, M. W.
October 23, 2020
PTSD and the Klotho Longevity Gene: Evaluation of Longitudinal Effects on Inflammation via DNA Methylation.
Wolf, EJ, Logue, WL, Zhao, X, Daskalakis, N, Morrison, FG, Escarfulleri, S, Stone, A, Schichman, SA, McGlinchey, RE, Milberg, WP, Chen, CD, Abraham, CR and Miller, MW
Wolf, EJ, Logue, WL, Zhao, X, Daskalakis, N, Morrison, FG, Escarfulleri, S, Stone, A, Schichman, SA, McGlinchey, RE, Milberg, WP, Chen, CD, Abraham, CR and Miller, MW
March 18, 2020
A method to specifically activate the Klotho promoter by using zinc finger proteins constructed from modular building blocks and from naturally engineered Egr1 transcription factor backbone
Ci-DiĀ Chen, Melissa A.Ā Rudy, EllaĀ Zeldich, Carmela R.Ā Abraham
Ci-DiĀ Chen, Melissa A.Ā Rudy, EllaĀ Zeldich, Carmela R.Ā Abraham
January 24, 2020
Identification of the cleavage sites leading to the shed forms of human and mouse anti-aging and cognition-enhancing protein Klotho.
Chen CD, Li Y, Chen AK, Rudy MA, Nasse JS, Zeldich E, Polanco TJ, Abraham CR
Chen CD, Li Y, Chen AK, Rudy MA, Nasse JS, Zeldich E, Polanco TJ, Abraham CR
January 13, 2020
Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress.
Delitsikou V, Jarad G, Rajaram RD, Ino F, Rutkowski JM, Chen CD, Santos CXC, Scherer PE, Abraham CR, Shah AM, Feraille E, Miner JH, de Seigneux S
Delitsikou V, Jarad G, Rajaram RD, Ino F, Rutkowski JM, Chen CD, Santos CXC, Scherer PE, Abraham CR, Shah AM, Feraille E, Miner JH, de Seigneux S
November 13, 2019
Klotho Is Neuroprotective in the Superoxide Dismutase mutase (SOD1G93A) Mouse Model of ALS
Zeldich, E, Chen, C-D, Boden, E, Howat, B, Nasse, JS, Zeldich, D, Lambert, AG, Yuste, A, Cherry, JD, Mathias, RM, Ma, Q, NC, McKee, AC, Hatzipetros, T, and Abraham, CR.
Zeldich, E, Chen, C-D, Boden, E, Howat, B, Nasse, JS, Zeldich, D, Lambert, AG, Yuste, A, Cherry, JD, Mathias, RM, Ma, Q, NC, McKee, AC, Hatzipetros, T, and Abraham, CR.
April 13, 2019
Circulating fibroblast growth factor 23 levels and incident dementia: The Framingham heart study.
McGrath, ER, Himali, JJ, Levy, D, Conner, SC, Pase, M, Abraham, CR, Courchesne, P, Satizabal, C, Vasan, RS, Beiser, A, Seshadri, S.
McGrath, ER, Himali, JJ, Levy, D, Conner, SC, Pase, M, Abraham, CR, Courchesne, P, Satizabal, C, Vasan, RS, Beiser, A, Seshadri, S.
March 4, 2019
Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling
Ci-Di Chen, Ella Zeldich, Christina Khodr, Kaddy Camara, Tze Yu Tung, Emma C Lauder, Patrick Mullen, Taryn J Polanco, Yen-Yu Liu, Dean Zeldich, Weiming Xia, William E Van Nostrand, Lauren E Brown, John A Porco, Carmela R Abraham
Ci-Di Chen, Ella Zeldich, Christina Khodr, Kaddy Camara, Tze Yu Tung, Emma C Lauder, Patrick Mullen, Taryn J Polanco, Yen-Yu Liu, Dean Zeldich, Weiming Xia, William E Van Nostrand, Lauren E Brown, John A Porco, Carmela R Abraham
February 1, 2019
Activation of the Anti-Aging and Cognition-Enhancing Gene Klotho by CRISPR-dCas9 Transcriptional Effector Complex
Ci-Di Chen, Ella Zeldich, Yuexuan Li, Andrea Yuste, Carmela R. Abraham
Ci-Di Chen, Ella Zeldich, Yuexuan Li, Andrea Yuste, Carmela R. Abraham
January 19, 2018
Klotho Is a Neuroprotective and Cognition-Enhancing Protein
Abraham CR, Mullen PC, Tucker-Zhou T, Chen CD, Zeldich E
Abraham CR, Mullen PC, Tucker-Zhou T, Chen CD, Zeldich E
June 1,2016
The anti-aging protein Klotho enhances remyelination following cuprizone-induced demyelination.
Zeldich, E, Chen,CD, Avila,Ā R, Medicetty, SĀ andĀ Abraham, CR
Zeldich, E, Chen,CD, Avila,Ā R, Medicetty, SĀ andĀ Abraham, CR
June 2, 2015
Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice.
Dubal, D, Zhu, L, Sanchez, P, Worden, K, Broestl, L, Yu, G-Q, Kim, D, Kuro-o, M,Ā Abraham, CR, Mucke, L
Dubal, D, Zhu, L, Sanchez, P, Worden, K, Broestl, L, Yu, G-Q, Kim, D, Kuro-o, M,Ā Abraham, CR, Mucke, L
February 11, 2015
Identification of cleavage sites leading to the shed form of the anti-aging protein Klotho.
Chen, C-D, Tung, T-Y, Liang, J, Zeldich, E, Turk, BE, andĀ Abraham, CR
Chen, C-D, Tung, T-Y, Liang, J, Zeldich, E, Turk, BE, andĀ Abraham, CR
August 11, 2014
The neuroprotective effect of Klotho is mediated via regulation of members of the redox system.
Zeldich, E, Chen, CD, Colvin, TA, Bove-Fenderson, EA, Liang, J, Tucker Zhou TB, Harris, DA andĀ Abraham, CR
Zeldich, E, Chen, CD, Colvin, TA, Bove-Fenderson, EA, Liang, J, Tucker Zhou TB, Harris, DA andĀ Abraham, CR
July 18, 2014
The Anti-Aging and Tumor Suppressor Protein Klotho Enhances Differentiation of a Human Oligodendrocytic Hybrid Cell Line.
Chen, CD, Hu Li, H, Liang, J, Hixson, K, Zeldich, E, andĀ Abraham, CR
Chen, CD, Hu Li, H, Liang, J, Hixson, K, Zeldich, E, andĀ Abraham, CR
June 8, 2014
Life extension factor klotho enhances cognition.
Dubal, DB, Yokoyama, JS, Zhu, L, Broestl, L, Worden, K, Wang, D, Sturm, VE, Kim, D. Klein, E. Yu, G-Q, Ho, K, Eilertson, KE, Yu, L, Makoto Kuro-o, M, De Jager, PL, Coppola, G, Small, GW, Bennett, DA, Kramer, JH,Ā Abraham, CR, Miller, BL, Mucke, L
Dubal, DB, Yokoyama, JS, Zhu, L, Broestl, L, Worden, K, Wang, D, Sturm, VE, Kim, D. Klein, E. Yu, G-Q, Ho, K, Eilertson, KE, Yu, L, Makoto Kuro-o, M, De Jager, PL, Coppola, G, Small, GW, Bennett, DA, Kramer, JH,Ā Abraham, CR, Miller, BL, Mucke, L
May 22, 2014
Biochemical and Functional Characterization of the Klotho VS Polymorphism Implicated in Aging and Disease Risk.
Tucker-Zhou, TB, King, GD, Chen, CD andĀ Abraham, CR
Tucker-Zhou, TB, King, GD, Chen, CD andĀ Abraham, CR
December 20, 2013
MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro.
Mehi, SJ, Maltare, A,Ā Abraham, CRĀ and King, GD
Mehi, SJ, Maltare, A,Ā Abraham, CRĀ and King, GD
July 2, 2013
The anti-aging protein Klotho enhances oligodendrocyte maturation and myelination of the central nervous system.
Chen, CD, Sloane, JA, Li, H, Aytan, N, Giannaris, EL, Zeldich, E, Hinman, JD, Dedeoglu, A, Rosene, DL, Bansal, R, Luebke, J, Makoto Kuro-o andĀ Abraham, CR
Chen, CD, Sloane, JA, Li, H, Aytan, N, Giannaris, EL, Zeldich, E, Hinman, JD, Dedeoglu, A, Rosene, DL, Bansal, R, Luebke, J, Makoto Kuro-o andĀ Abraham, CR
January 30, 2013
Small-molecule Klotho enhancers as novel treatment of neurodegeneration
Carmela R Abraham, CiDi Chen, Gregory D Cuny, Marcie A Glicksman & Ella Zeldich
Carmela R Abraham, CiDi Chen, Gregory D Cuny, Marcie A Glicksman & Ella Zeldich
September 1, 2012
Identiļ¬cation of novel small molecules that elevate Klotho expression
Gwendalyn D. KING, CiDi CHEN, Mickey M. HUANG, Ella ZELDICH, Patricia L. BRAZEE, Eli R. SCHUMAN, Maxime ROBIN, Gregory D. Cuny, Marcie A. Glicksman, Carmela R. Abraham
Gwendalyn D. KING, CiDi CHEN, Mickey M. HUANG, Ella ZELDICH, Patricia L. BRAZEE, Eli R. SCHUMAN, Maxime ROBIN, Gregory D. Cuny, Marcie A. Glicksman, Carmela R. Abraham
September 22, 2011
Promoter methylation and age-related downregulation of klotho in rhesus monkey.
King, GD, Rosene, DL andĀ Abraham, CR
King, GD, Rosene, DL andĀ Abraham, CR
September 16, 2011
Insulin Stimulates the Cleavage and Release of the Extracellular Domain of Klotho via ADAM10 and ADAM17,Ā PNAS. 104:19796-801.
Chen, C-D, Podvin, S, Gillespie, E, Leeman, S andĀ Abraham, CR
Chen, C-D, Podvin, S, Gillespie, E, Leeman, S andĀ Abraham, CR
December 3, 2007
Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey.Ā Glia. 56:106-17.
Duce, JA, Podvin, S, Hollander, W, Kipling, D, Rosene, DL andĀ Abraham, CR
Duce, JA, Podvin, S, Hollander, W, Kipling, D, Rosene, DL andĀ Abraham, CR
October 26, 2007Select relevant papers published by other labs:
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Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk
Muhammad Ali, Yun Ju Sung, Fengxian Wang , Maria V. Fernández, John C. Morris, Anne M. Fagan, Kaj Blennow, Henrik Zetterberg, Amanda Heslegrave, Per M. Johansson, Johan Svensson, Bengt NellgĆ„rd, Alberto Lleó, Daniel Alcolea, Jordi Clarimon, Lorena Rami, José Luis Molinuevo, Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Christian Haass, Michael Ewers, Johannes Levin, Martin R. Farlow, Richard J. Perrin, on behalf of the Alzheimerās Disease Neuroimaging Initiative (ADNI), on behalf of the Dominantly Inherited Alzheimer Network (DIAN), Carlos Cruchaga
May 26, 2022 -
KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease
Julia Neitzel, Nicolai Franzmeier, Anna Rubinski, Martin Dichgans, Matthias Brendel, Alzheimerās Disease Neuroimaging Initiative (ADNI); Rainer Malik, Michael Ewers
June 22, 2021 -
Association of Klotho-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry APOE4
Michael E. Belloy, PhD; Valerio Napolioni, PhD; Summer S. Han, PhD; Yann Le Guen, PhD; Michael D. Greicius, MD, MPH; for the Alzheimerās Disease Neuroimaging Initiative
April 13, 2020 -
Klotho controls the braināimmune system interface in the choroid plexus
Zhu, L, Stein, LR, Kim, D, Ho, K, Yu, G-Q, Zhan, L, Larsson, ET and Mucke, L
November 9, 2019 -
Klotho deficiency affects the spine morphology and network synchronization of neurons.
Vo HT, Phillips ML, Herskowitz JH, King GD
July 1, 2019 -
KLOTHOĀ heterozygosity attenuatesĀ APOE4-related amyloid burden in preclinical AD. Neurology.
Erickson CM, Schultz SA, Oh JM, Darst BF, Ma Y, Norton D, Betthauser T, Gallagher CL, Carlsson CM, Bendlin BB, Asthana S, Hermann BP, Sager MA, Blennow K, Zetterberg H, Engelman CD, Christian BT, Johnson SC, Dubal DB, Okonkwo OC
April 16, 2019 -
Enhanced Expression of Secreted Ī±-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice.
Li D, Jing D, Liu Z, Chen Y, Huang F and Behnisch T
April 2, 2019 -
FGF-23 Deficiency Impairs Hippocampal-Dependent Cognitive Function.
Laszczyk AM, Nettles D, Pollock TA, Fox S, Garcia ML, Wang J, Quarles LD, King GD
March 22, 2019 -
Klotho, the Key to Healthy Brain Aging?
Vo, HT, Laszczyk, AM and King, GD
August 10, 2018 -
Lentivirus-mediatedĀ klothoĀ up-regulation improves aging-related memory deficits and oxidative stress in senescence-accelerated mouse prone-8 mice.
Zhou HJ,Ā Zeng CY,Ā Yang TT,Ā Long FY,Ā Kuang X,Ā Du JR
May 1, 2018 -
Secreted Ī±Klotho isoform protects against age-dependent memory deficits.
Masso, A, Sanchez, A, Bosch, A, Gimenez-Llort, L, Chillon, M
October 31, 2017 -
Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and Ī±-Synuclein Transgenic Mice.
Leon J, Moreno AJ, Garay BI, Chalkley RJ, Burlingame AL, Wang D, Dubal DB
August 8, 2017 -
Secreted and Transmembrane Ī±Klotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression.
MassĆ³ A, SĆ”nchez A, Gimenez-Llort L, Lizcano JM, CaƱete M, GarcĆa B, Torres-Lista V, Puig M, Bosch A, Chillon M
November 24, 2015