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“The Anti-Aging Protein Klotho: A novel therapeutic target for neurodegenerative diseases”
2020 Virtual Symposium / Carmela Abraham of Boston University at Massachusetts General Hospital
August 2020


Relevant papers published by Drs. Carmela Abraham, Cidi Chen, Ella Zeldich and collaborators include:

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AAV-mediated expression of secreted and transmembrane š›¼Klotho isoforms rescues relevant aging hallmarks in senescent SAMP8 mice

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A Transgenic Model Reveals the Role of Klotho in Pancreatic Cancer Development and Paves the Way for New Klotho-Based Therapy

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miR-142-3p Regulates Cortical Oligodendrocyte Gene Co-expression Networks Associated with Tauopathy.

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Klotho, PTSD, and advanced epigenetic age in cortical tissue.

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PTSD and the Klotho Longevity Gene: Evaluation of Longitudinal Effects on Inflammation via DNA Methylation.

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A method to specifically activate the Klotho promoter by using zinc finger proteins constructed from modular building blocks and from naturally engineered Egr1 transcription factor backbone

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Identification of the cleavage sites leading to the shed forms of human and mouse anti-aging and cognition-enhancing protein Klotho.

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Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress.

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Klotho Is Neuroprotective in the Superoxide Dismutase mutase (SOD1G93A) Mouse Model of ALS

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Circulating fibroblast growth factor 23 levels and incident dementia: The Framingham heart study.

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Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling

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Activation of the Anti-Aging and Cognition-Enhancing Gene Klotho by CRISPR-dCas9 Transcriptional Effector Complex

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Klotho Is a Neuroprotective and Cognition-Enhancing Protein

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The anti-aging protein Klotho enhances remyelination following cuprizone-induced demyelination.

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Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice.

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Identification of cleavage sites leading to the shed form of the anti-aging protein Klotho.

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The neuroprotective effect of Klotho is mediated via regulation of members of the redox system.

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The Anti-Aging and Tumor Suppressor Protein Klotho Enhances Differentiation of a Human Oligodendrocytic Hybrid Cell Line.

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Life extension factor klotho enhances cognition.

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Biochemical and Functional Characterization of the Klotho VS Polymorphism Implicated in Aging and Disease Risk.

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MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro.

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The anti-aging protein Klotho enhances oligodendrocyte maturation and myelination of the central nervous system.

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Small-molecule Klotho enhancers as novel treatment of neurodegeneration

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Identiļ¬cation of novel small molecules that elevate Klotho expression

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Promoter methylation and age-related downregulation of klotho in rhesus monkey.

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Insulin Stimulates the Cleavage and Release of the Extracellular Domain of Klotho via ADAM10 and ADAM17,Ā PNAS. 104:19796-801.

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Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey.Ā Glia. 56:106-17.

Select relevant papers published by other labs: