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Prevention and treatment of age-related diseases


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Nephrology

  1. Hu MC, Shi M, Zhang J, et al. Renal production, uptake, and handling of circulating alphaKlotho. J Am Soc Nephrol. 2016;27:79–90.
  2. Hu MC, Shiizaki K, Kuro-o M, et al. Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism. Annu Rev Physiol.2013;75:503–533.
  3. Lindberg K, Amin R, Moe OW, et al. The kidney is the principal organ mediating klotho effects. J Am Soc Nephrol. 2014;25:2169–2175.
  4. Barker SL, Pastor J, Carranza D, et al. The demonstration of alphaKlotho eficiency in human chronic kidney disease with a novel synthetic antibody. Nephrol Dial Transplant. 2015;30:223–233.
  5. Hu MC, Shi M, Cho HJ, et al. Klotho and phosphate are modulators of pathologic uremic cardiac remodeling. J Am Soc Nephrol. 2015;26: 1290–1302.
  6. Hu MC, Shi M, Zhang J, et al. Klotho deficiency causes vascular calcification in chronic kidney disease. J Am Soc Nephrol. 2011;22:124–136.
  7. Ravikumar P, Li L, Ye J, et al. alphaKlotho deficiency in acute kidney injury contributes to lung damage. J Appl Physiol (1985). 2016;120:723–732.
  8. Hu MC, Shi M, Zhang J, et al. Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective. Kidney Int. 2010;78:1240–1251.
  9. Hu MC, Kuro-o M, Moe OW. Klotho and kidney disease. J Nephrol. 2010;23(Suppl 16):S136–S144.
  10. Hu MC, Shi M, Zhang J, et al. Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J. 2010;24:3438–3450.
  11. Shi M, Flores B, Gillings N, et al. alphaKlotho mitigates progression of AKI to CKD through activation of autophagy. J Am Soc Nephrol. 2016;27: 2331–2345.
  12. Cha SK, Hu MC, Kurosu H, et al. Regulation of renal outer medullary potassium channel and renal K(þ) excretion by Klotho. Mol Pharmacol. 2009;76:38–46.
  13. Panesso MC, Shi M, Cho HJ, et al. Klotho has dual protective effects on cisplatin-induced acute kidney injury. Kidney Int. 2014;85: 855–870.
  14. Bian A, Xing C, Hu MC. Alpha Klotho and phosphate homeostasis.J Endocrinol Invest. 2014;37:1121–1126.
  15. Ikushima M, Rakugi H, Ishikawa K, et al. Anti-apoptotic and anti- senescence effects of Klotho on vascular endothelial cells. Biochem Biophys Res Commun. 2006;339:827–832.
  16. Xie J, Yoon J, An SW, et al. Soluble Klotho protects against uremic cardiomyopathy independently of fibroblast growth factor 23 and phosphate. J Am Soc Nephrol. 2015;26:1150–1160.
  17. Hu MC, Kuro-o M, Moe OW. The emerging role of Klotho in clinical nephrology. Nephrol Dial Transplant. 2012;27:2650–2657.
  18. Lau WL, Leaf EM, Hu MC, et al. Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet. Kidney Int. 2012;82: 1261–1270.
  19. Hu MC. Klotho connects intermedin1-53 to suppression of vascular calcification in chronic kidney disease. Kidney Int. 2016;89:534–537. Bucaloiu ID, Kirchner HL, Norfolk ER, et al. Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury. Kidney Int. 2012;81:477–485.
  20. Liu F, Wu S, Ren H, et al. Klotho suppresses RIG-I-mediated senescence- associated inflammation. Nat Cell Biol. 2011;13:254–262.
  21. Hu MC, Shi M, Cho HJ, et al. The erythropoietin receptor is a downstream effector of Klotho-induced cytoprotection. Kidney Int. 2013;84:468–481.
  22. Yamamoto M, Clark JD, Pastor JV, et al. Regulation of oxidative stress by the anti-aging hormone klotho. J Biol Chem. 2005;280:38029–38034.
  23. Kim JH, Xie J, Hwang KH, et al. Klotho may ameliorate proteinuria by targeting TRPC6 channels in podocytes [e-bup ahead of print]. J Am Soc Nephrol. http://dx.doi.org/10.1681/ASN.2015080888.
  24. Xie J, Cha SK, An SW, et al. Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart. Nat Commun. 2012;3:1238.
  25. Gutierrez OM. Fibroblast growth factor 23, Klotho, and disordered mineral metabolism in chronic kidney disease: unraveling the intricate tapestry of events and implications for therapy. J Ren Nutr. 2013;23: 250–254.